Published Work

Dynamic regulation of gonadal transposon control across the lifespan of the naturally short-lived African turquoise killifish

Bryan B Teefy, Ari Adler, Alan Xu, Katelyn Hsu, Param Priya Singh, Berenice A Benayoun

Genome Research, 2022

An automated feeding system for the African killifish reveals effects of dietary restriction on lifespan and allows scalable assessment of associative learning

Andrew McKay, Emma K Costa, Jingxun Chen, Chi-Kuo Hu, Xiaoshan Chen, Claire Nicole Bedbrook, Rishad C Khondker, Mike Thielvoldt, Param Priya Singh, Tony Wyss-Coray, Anne Brunet

Elife, 2022

Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate

Yiwen R Chen*, Itamar Harel*, Param Priya Singh, Inbal Ziv, Eitan Moses, Uri Goshtchevsky, Ben E Machado, Anne Brunet, Daniel F Jarosz

bioRxiv, 2022 [Preprint]

Identification of protein aggregates in the aging vertebrate brain with prion-like and phase separation properties

Itamar Harel*, Yiwen R Chen*, Inbal Ziv, Param Priya Singh, Paloma Navarro Negredo, Uri Goshtchevsky, Wei Wang, Gwendoline Astre, Eitan Moses, Andrew McKay, Ben E Machado, Katja Hebestreit, Sifei Yin, Alejandro Sánchez Alvarado, Daniel F Jarosz, Anne Brunet

bioRxiv, 2022 [Preprint]

Evolution of diapause in the African turquoise killifish by remodeling ancient gene regulatory landscape

Param Priya Singh*, G Adam Reeves*, Kévin Contrepois, Mathew Ellenberger, Chi-Kuo Hu, Michael P Snyder, Anne Brunet

bioRxiv, 2021 [Preprint]

Vertebrate diapause preserves organisms long term through Polycomb complex members

Chi-Kuo Hu, Wei Wang, Julie Brind’Amour, Param Priya Singh, G Adam Reeves, Matthew C Lorincz, Alejandro Sánchez Alvarado, Anne Brunet

Science, 2020

Mutations in calmodulin-binding domains of TRPV4/6 channels confer invasive properties to colon adenocarcinoma cells

Atousa Arbabian, Mircea Iftinca, Christophe Altier, Param Priya Singh, Hervé Isambert, Sylvie Coscoy

Channels, 2020

The genetics of aging: a vertebrate perspective

Param Priya Singh*, Brittany A Demmitt*, Ravi D Nath*, Anne Brunet

Cell, 2019

OHNOLOGS v2: A comprehensive resource for the genes retained from whole genome duplication in vertebrates

Param Priya Singh, Hervé Isambert

Nucleic Acids Research, 2019

Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

Bérénice A Benayoun, Elizabeth A Pollina, Param Priya Singh, Salah Mahmoudi, Itamar Harel, Kerriann M Casey, Ben W Dulken, Anshul Kundaje, Anne Brunet

Genome Research, 2019

The genome of Austrofundulus limnaeus offers insights into extreme vertebrate stress tolerance and embryonic development

Josiah T Wagner, Param Priya Singh, Amie L Romney, Claire L Riggs, Patrick Minx, Steven C Woll, Jake Roush, Wesley C Warren, Anne Brunet, Jason E Podrabsky

BMC Genomics, 2018

Progranulin, lysosomal regulation and neurodegenerative disease

Aimee W Kao, Andrew McKay, Param Priya Singh, Anne Brunet, Eric J Huang

Nature Neuroscience, 2017

Learning causal networks with latent variables from multivariate information in genomic data

Louis Verny, Nadir Sella, Séverine Affeldt, Param Priya Singh, Hervé Isambert

PLOS Computational Biology, 2017

The African turquoise killifish genome provides insights into evolution and genetic architecture of lifespan

Dario R Valenzano*, Bérénice A Benayoun*, Param Priya Singh*, Elisa Zhang, Paul D Etter, Chi-Kuo Hu, Mathieu Clément-Ziza, David Willemsen, Rongfeng Cui, Itamar Harel, Ben E Machado, Muh-Ching Yee, Sabrina C Sharp, Carlos D Bustamante, Andreas Beyer, Eric A Johnson, Anne Brunet

Cell, 2015

A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate

Itamar Harel, Bérénice A Benayoun, Ben Machado, Param Priya Singh, Chi-Kuo Hu, Matthew F Pech, Dario R Valenzano, Elisa Zhang, Sabrina C Sharp, Steven E Artandi, Anne Brunet

Cell, 2015

Identification of ohnolog genes originating from whole genome duplication in early vertebrates, based on synteny comparison across multiple genomes

Param Priya Singh, Jatin Arora, Hervé Isambert

PLOS Computational Biology, 2015

Human dominant disease genes are enriched in paralogs originating from whole genome duplication

Param Priya Singh, Séverine Affeldt, Giulia Malaguti, Hervé Isambert

PLOS Computational Biology, 2014

On the retention of gene duplicates prone to dominant deleterious mutations

Giulia Malaguti, Param Priya Singh, Hervé Isambert

Theoretical Population Biology, 2014

On the expansion of "dangerous" gene repertoires by whole-genome duplications in early vertebrates

Param Priya Singh*, Séverine Affeldt*, Ilaria Cascone, Rasim Selimoglu, Jacques Camonis, Hervé Isambert

Cell Reports, 2012

Case for an RNA-prion world: a hypothesis based on conformational diversity

Param Priya Singh, Anirban Banerji

Journal of Biological Physics, 2011

© Singh lab UCSF, 2023